生物合成工程实验室
Biosynthetic Engineering Laboratory

生物合成工程实验室致力于代谢工程、合成生物学和分子生理学研究，已建立了成熟的大肠杆菌、毕赤酵母和链霉菌的遗传操作平台。与生物过程工程研究相补充和支持，构建高效的细胞工厂，服务于工业生物技术、农业生物技术、医药生物技术和环境生物技术等多个生物技术领域。
Our research work focuses on metabolic engineering, synthetic biology and molecular physiology on the basis of the well-established platforms for genetic manipulation of E. coli, P. pastoris and Streptomyces ssp.. Combined with the bioprocess engineering, we are harnessing the synthetic power of biology to build microbial cell factories for industrial, agricultural, medical, and environmental applications.


研究成果
1.GAP promoter library for fine-tuning gene expression in Pichia pastoris. Applied and Environmental Microbiology. 2011, 77: 3600-3608.
2.Reliable high-throughput approach for screening of engineered constitutive promoters in the yeast Pichia pastoris. Letters in Applied Microbiology. 2011, 52: 634-641.
3.Toward improvement of erythromycin A production in an industrial Saccharopolyspora erythraea strain via facilitation of genetic manipulation with an artificial attB site for specific recombination. Applied and Environmental Microbiology. 2011, 77: 7508-7516.
4.Progress in the research of S-adenosyl-L-methionine production. Applied Microbiology and Biotechnology. 2013, 97: 41-49.
5.Impacts of high β-galactosidase expression on central metabolism of recombinant Pichia pastoris GS115 using glucose as sole carbon source via 13C metabolic flux analysis. Journal of Biotechnology. 2014, 187: 124-134.
专利
1.GAP启动子文库在调节S-腺苷甲硫氨酸代谢途径中的应用. 专利号 ZL 201010621230.1
2.GAP启动子文库及其用途. 专利号 ZL 200910053198.9